SWI/SNF: The crossroads where extracellular signaling pathways meet chromatin

被引：82
|
作者：
Simone, C [1 ]
机构：
[1] Univ Bari, Dept Biomed Childhood, Div Med Genet, I-70124 Bari, Italy
[2] Temple Univ, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2006年 / 207卷 / 02期
关键词：
D O I：
10.1002/jcp.20514
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The coordinated expression of the genome in response to extracellular cues is ensured by enzymatic cascades signaling to the nucleus. These pathways generate chromatin modifications at specific loci controlling the transcription of signal-dependent and tissue-specific genes. The SWI/SNF chromatin remodeling complex offers the ideal surface for integrating these signals in the execution of diverse or even opposite biological programs. J. Cell. Physiol. 207:-309-314, 2006. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码：309 / 314
页数：6
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