Lowering Low-Density Lipoprotein Cholesterol: Statins, Ezetimibe, Bile Acid Sequestrants, and Combinations: Comparative Efficacy and Safety

被引：74
|
作者：
Hou, Runhua [2 ]
Goldberg, Anne Carol [1 ]
机构：
[1] Washington Univ, Div Endocrinol Metab & Lipid Res, Sch Med, St Louis, MO 63110 USA
[2] Univ Rochester, Endocrine Unit, Rochester, NY 14642 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2009年 / 38卷 / 01期
关键词：
LDL-C; Statins; Ezetimibe; Bile acid sequestrants; Efficacy; Safety; CORONARY-ARTERY-DISEASE; EXTENDED-RELEASE NIACIN; COLESEVELAM HYDROCHLORIDE; PRIMARY HYPERCHOLESTEROLEMIA; COMBINED HYPERLIPIDEMIA; DOUBLE-BLIND; FAMILIAL HYPERCHOLESTEROLEMIA; ENTEROHEPATIC CIRCULATION; ABSORPTION INHIBITOR; LOVASTATIN THERAPY;
D O I：
10.1016/j.ecl.2008.11.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.
引用
收藏
页码：79 / +
页数：20
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