Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception

被引:7
|
作者
Tseng, Ming-Tsung [1 ]
Kong, Yazhuo [2 ,3 ]
Chiang, Ming-Chang [4 ]
Chao, Chi-Chao [5 ]
Tseng, Wen-Yih I. [6 ]
Hsieh, Sung-Tsang [1 ,5 ,7 ]
机构
[1] Natl Taiwan Univ, Coll Med, Grad Inst Brain & Mind Sci, Taipei 10051, Taiwan
[2] Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford, England
[3] Univ Oxford, Nuffield Div Anaesthet, Nuffield Dept Clin Neurosci, Oxford, England
[4] Natl Yang Ming Univ, Dept Biomed Engn, Taipei 112, Taiwan
[5] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan
[6] Natl Taiwan Univ Hosp, Ctr Optoelect Biomed, Taipei, Taiwan
[7] Natl Taiwan Univ Hosp, Dept Anat & Cell Biol, Taipei, Taiwan
关键词
Contact heat-evoked potential; Functional magnetic resonance imaging (fMRI); Psychophysical interaction analysis; Skin innervation; Pain; Heat; SINGLE-TRIAL FMRI; FUNCTIONAL CONNECTIVITY; SOMATOSENSORY CORTEX; ANTERIOR INSULA; THERMAL PAIN; RESPONSES; HUMANS; REPRESENTATION; DEGENERATION; ACTIVATIONS;
D O I
10.1016/j.neuroimage.2015.08.021
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although the small-diameter primary afferent fibers in the skin promptly respond to nociceptive stimuli and convey sensory inputs to the central nervous system, the neural signatures that underpin the relationship between cutaneous afferent fibers and pain perception remain elusive. We combined skin biopsy at the lateral aspect of the distal leg, which is used to quantify cutaneous afferent fibers, with fMRI, which is used to assess brain responses and functional connectivity, to investigate the relationship between cutaneous sensory nerves and the corresponding pain perception in the brain after applying heat pain stimulation to the dorsum of the right foot in healthy subjects. During painful stimulation, the degree of cutaneous innervation, as measured by epidermal nerve fiber density, was correlated with individual blood oxygen level-dependent (BOLD) signals of the posterior insular cortex and of the thalamus, periaqueductal gray, and rostral ventromedial medulla. Pain perception was associated with the activation of the anterior insular cortex and with the functional connectivity from the anterior insular cortex to the primary somatosensory cortex during painful stimulation. Most importantly, both epidermal nerve fiber density and activity in the posterior insular cortex showed a positive correlation with the strength of coupling under pain between the anterior insular cortex and the primary somatosensory cortex. Thus, our findings support the notion that the neural circuitry subserving pain perception interacts with the cerebral correlates of peripheral nociceptive fibers, which implicates an indirect role for skin nerves in human pain perception. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:288 / 297
页数:10
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