Three new cryptophycins from Nostoc sp. GSV 224

被引：69
|
作者：
Subbaraju, GV [1 ]
Golakoti, T [1 ]
Patterson, GML [1 ]
Moore, RE [1 ]
机构：
[1] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822
来源：
JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 03期
关键词：
D O I：
10.1021/np960700a
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Cryptophycin 46 (2), -175 (3), and -176 (4) have been identified as three new trace constituents of Nostoc sp. GSV 224. Cryptophycin-46 is an epimer of cryptophycin-3 (5) and to date is the only naturally occurring analogue having the S configuration at C-10 (C-2 in Unit B). Cryptophycins-175 and -176 also differ in unit B where 3 is the O-methyl analogue of cryptophycin-45 (6) and 4 is the O-desmethyl analogue of cryptophycin-21 (8). The relative and absolute stereochemistries of the three new analogues have been related to known cryptophycins by synthesis.
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收藏
页码：302 / 305
页数：4
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