THE IN VITRO RELEASE MECHANISM OF IBUPROFEN FROM CONVENTIONAL AND SPECIAL DOSAGE FORMS

Six pharmaceutical dosage forms (sugar coated tablets, hard and soft gelatin capsules, oral suspension and rectal suppositories), containing various concentrations of ibuprofen as single active ingredient, were evaluated in vitro, based on the available compendial recommendations. Several methodological adaptions were implemented, in order to adequately address the particularities of the formulations and the rate-limiting step of the release process. The analysis of the mean dissolution profiles was focused on applicability of different kinetic models, possible explanations for observed similarities or non-similarities and on the foreseen limitations in applicability of the test conditions, in the context of biowaiver.