WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study

被引：60

作者：

Yanagisawa, Ryu ^{[1
]}

Koizumi, Tomonobu ^{[2
]}

Koya, Terutsugu ^{[4
]}

Sano, Kenji ^{[3
]}

Koido, Shigeo ^{[5
]}

Nagai, Kazuhiro ^{[6
]}

Kobayashi, Masanori ^{[7
]}

Okamoto, Masato ^{[7
]}

Sugiyama, Haruo ^{[8
]}

Shimodaira, Shigetaka ^{[4
]}

机构：

[1] Shinshu Univ Hosp, Ctr Adv Cell Therapy, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ Hosp, Shinshu Canc Ctr, Matsumoto, Nagano, Japan

[3] Shinshu Univ Hosp, Dept Lab Med, Matsumoto, Nagano, Japan

[4] Kanazawa Med Univ, Dept Regenerat Med, Uchinada, Ishikawa, Japan

[5] Jikei Univ, Sch Med, Dept Gastroenterol & Hepatol, Kashiwa, Chiba, Japan

[6] Nagasaki Univ Hosp, Transfus & Cell Therapy Unit, Sakamoto, Japan

[7] Osaka Univ, Grad Sch Pharmaceut Sci, Dept Adv Immunotherapeut, Suita, Osaka, Japan

[8] Osaka Univ, Dept Funct Diagnost Sci, Grad Sch Med, Suita, Osaka, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 04期

关键词：

DC vaccine; immunotherapy; S-1; T cell; WT1; WILMS-TUMOR; 1; STREPTOCOCCAL PREPARATION; DUCTAL ADENOCARCINOMA; GENE WT1; IMMUNOTHERAPY; GEMCITABINE; OK-432; ANTIGEN; S-1; COMBINATION;

D O I：

10.21873/anticanres.12464

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Wilms' tumor 1 (WT1) is a tumor-associated antigen highly expressed in cancer. We examined the safety of WT1-peptide pulsed dendritic cell (WT1-DC) vaccine in combination with chemotherapy in patients with surgically resected pancreatic cancer. Patients and Methods: Eight patients with resectable pancreatic cancer undergoing surgery either combined with S-1 or S-1 plus gemcitabine therapy were enrolled. Immunohistochemical analysis of WT1 was performed in 34 cases of pancreatic cancer. Results: No serious side-effects were observed, except grade I fever in five and grade I reactions at the injection site in all patients. WT1-specific cytotoxic T-lymphocytes were detected in seven patients, and WT1 and human leukocyte antigen class I antigens were positive in all 34 cases. Conclusion: Our study clarified the safety and potential acquisition of immunity after vaccination targeting WT1. Further efficacy of WT1-DC vaccine to improve prognosis would be determined by a prospective clinical trial for resectable pancreatic cancer.

引用

页码：2217 / 2225

页数：9

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