Autophagy as a macrophage response to bacterial infection

被引：37
|
作者：
Gong, Lan [1 ,2 ]
Devenish, Rodney J. [1 ,2 ]
Prescott, Mark [1 ]
机构：
[1] Monash Univ, Dept Biochem & Mol Biol, Clayton Campus, Vic 3800, Australia
[2] Monash Univ, ARC Ctr Excellence Struct & Funct Microbial Genom, Clayton Campus, Vic 3800, Australia
来源：
IUBMB LIFE | 2012年 / 64卷 / 09期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
autophagy; innate immunity; intracellular bacteria; macrophage; phagocytosis; LISTERIA-MONOCYTOGENES; CELL-DEATH; UBIQUITIN; IMMUNITY; SHIGELLA; PHAGOCYTOSIS; STIMULATION; SUPPRESSES; MECHANISMS; SUBVERSION;
D O I：
10.1002/iub.1070
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The macrophage is a key component of host defense mechanisms against pathogens. In addition to the phagocytosis of bacteria and secretion of proinflammatory mediators by macrophages, autophagy, a process involved in turnover of cellular material, is a recently identified component of the immune response to bacterial infection. Despite the bactericidal effect of autophagy, some species of intracellular bacteria are able to survive by using one or more strategies to avoid host autophagic attack. Here, we review the latest findings on the interactions between bacteria and autophagy in macrophages. (c) 2012 IUBMB Life, 64(9): 740747, 2012
引用
收藏
页码：740 / 747
页数：8
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