FGF23 Level and Intima-Media Thickness Are Elevated From Early Stages of Chronic Kidney Disease

Considering high cardiovascular (CV) risk in chronic kidney disease (CKD), the aim of this cross-sectional study was to assess the association between carotid intima-media thickness (IMT) and fibroblast growth factor (FGF) 23 as important players in CV pathophysiology. Eighty-seven patients with mean estimated glomerular filtration rate 40.1mL/min per 1.73m(2) were involved. FGF23 and IMT were elevated from early stages of CKD. Mean IMT value was 1.10 +/- 0.20mm, being significantly elevated starting from early CKD, showing no correlation with FGF23 (r=-0.01, P=-0.91). Unlike the FGF23 level that followed worsening of kidney function, IMT was increasing only in the initial CKD stages, with no further increase from CKD stage 3 on. Although we found no direct association between current use of vitamin D and statin therapy, this may be associated with the sustained reference values of lipid and vitamin D status under treatment that further preclude worsening of IMT in patients with advanced CKD.