The effects of erythropoietin on neurogenesis after ischemic stroke

被引：9
|
作者：
Zhang, Si-Jia [1 ,2 ,3 ]
Luo, Yu-Min [1 ,2 ,3 ,4 ]
Wang, Rong-Liang [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Inst Cerebrovasc Dis Res, Xuanwu Hosp, Beijing 100053, Peoples R China
[2] Beijing Geriatr Med Res Ctr, Beijing 100053, Peoples R China
[3] Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100053, Peoples R China
[4] Beijing Inst Brain Disorders, Beijing 100053, Peoples R China
来源：
JOURNAL OF INTEGRATIVE NEUROSCIENCE | 2020年 / 19卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Erythropoietin; neurogenesis; ischemic stroke; clinical translation; neurology; BLOOD-BRAIN-BARRIER; RECOMBINANT-HUMAN-ERYTHROPOIETIN; TISSUE-PLASMINOGEN ACTIVATOR; FOCAL CEREBRAL-ISCHEMIA; HIPPOCAMPAL NEUROGENESIS; CARBAMYLATED ERYTHROPOIETIN; SUBVENTRICULAR ZONE; NEURONAL PROGENITORS; RECEPTOR EXPRESSION; NEURITE OUTGROWTH;
D O I：
10.31083/j.jin.2020.03.4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Erythropoietin has been researched for its neuroprotective effects in ischemic stroke for over 30 years. Although erythropoietin can cause side effects that need to be controlled, it has been suggested to be effective in enhancing the prognosis of patients who are out of the therapeutic time window and have not received recombinant tissue plasminogen activator therapy. Studies on the mechanism of the function of erythropoietin have shown that it has various protective effects in ischemic brain injury after stroke, including promoting neurogenesis. In this review, we discuss the effects of erythropoietin on neurogenesis after ischemic brain injury and provide references for effective treatments for ischemic stroke, which is one of the leading causes of death worldwide.
引用
收藏
页码：561 / 570
页数：10
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