Field models and numerical dosimetry inside an extremely-low-frequency electromagnetic bioreactor: the theoretical link between the electromagnetically induced mechanical forces and the biological mechanisms of the cell tensegrity

被引：18

作者：

Mognaschi, Maria Evelina ^{[1
]}

Di Barba, Paolo ^{[1
]}

Magenes, Giovanni ^{[1
,2
]}

Lenzi, Andrea ^{[3
]}

Naro, Fabio ^{[4
]}

Fassina, Lorenzo ^{[1
,2
]}

机构：

[1] Univ Pavia, Dipartimento Ingn Ind & Informaz, I-27100 Pavia, Italy

[2] Univ Pavia, Ctr Ingn Tissutale, I-27100 Pavia, Italy

[3] Univ Roma La Sapienza, Dipartimento Med Sperimentale, Rome, Italy

[4] Univ Roma La Sapienza, Dipartimento Sci Anat, Istol Med Legali & Apparato Locomotore, Rome, Italy

来源：

SPRINGERPLUS | 2014年 / 3卷

关键词：

Electromagnetic field models; Numerical electromagnetic dosimetry; Magnetic induction field; Induced electric field; Induced electric currents; Induced mechanical forces; Tensegrity; CALCIFIED MATRIX PRODUCTION; MAGNETIC-FIELDS; ADENOSINE RECEPTORS; SAOS-2; OSTEOBLASTS; OSTEOGENIC DIFFERENTIATION; DOPAMINE-RECEPTORS; 5-HT1B RECEPTOR; STIMULATION; EXPOSURE; BRAIN;

D O I：

10.1186/2193-1801-3-473

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have implemented field models and performed a detailed numerical dosimetry inside our extremely-low-frequency electromagnetic bioreactor which has been successfully used in in vitro Biotechnology and Tissue Engineering researches. The numerical dosimetry permitted to map the magnetic induction field (maximum module equal to about 3.3 mT) and to discuss its biological effects in terms of induced electric currents and induced mechanical forces (compression and traction). So, in the frame of the tensegrity-mechanotransduction theory of Ingber, the study of these electromagnetically induced mechanical forces could be, in our opinion, a powerful tool to understand some effects of the electromagnetic stimulation whose mechanisms remain still elusive.

引用

页数：12