A general one-step synthesis of β-nitronitriles

被引：39
|
作者：
Anderson, James C. [1 ]
Blake, Alexander J. [1 ]
Mills, Matthew [1 ]
Ratcliffe, Paul D. [2 ]
机构：
[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England
[2] Schering Plough Corp, Dept Med Chem, Glasgow, Lanark, Scotland
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 18期
关键词：
D O I：
10.1021/ol801691c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The unusual beta-nitronitrile functionality was prepared by a simple one-step hydrocyanation of nitroalkenes. These compounds were shown to be precursors to monoprotected 1,3-diamines and 1,3-amino alcohols through the in situ formation of an alpha-cyano-aldenyde.
引用
收藏
页码：4141 / 4143
页数：3
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