Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid

被引:6
|
作者
Vukelic, Marija D. [1 ]
Mitic, Zarko J. [2 ]
Miljkovic, Miroslav S. [3 ]
Zivkovic, Jelena M. [1 ]
Ignjatovic, Nenad L. [4 ]
Uskokovic, Dragan P. [4 ]
Zivanov-Curlis, Jelena Z. [1 ]
Vasiljevic, Perica J. [5 ]
Najman, Stevo J. [1 ]
机构
[1] Univ Nis, Inst Biol & Human Genet, Fac Med, Nish 18000, Serbia
[2] Univ Nis, Dept Pharm, Fac Med, Nish 18000, Serbia
[3] Univ Nis, Lab Elect Microscopy, Fac Med, Nish 18000, Serbia
[4] SASA, Inst Tech Sci, Belgrade, Serbia
[5] Univ Nis, Biol & Ecol Dept, Fac Nat & Sci, Nish 18000, Serbia
关键词
EDS; IR spectroscopy; Nanomaterial; N-CP/PLGA; SEM; COMPOSITE; GLASS; BIOMATERIAL; DEGRADATION; SCAFFOLDS; POLYMERS; ACID;
D O I
10.5301/JABFM.2012.9274
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-DL-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.
引用
收藏
页码:43 / 48
页数:6
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