Biomaterials and Scaffolds in Bone and Musculoskeletal Engineering

被引：30
|
作者：
Kosuge, Dennis [1 ]
Khan, Wasim S. [2 ]
Haddad, Behrooz [2 ]
Marsh, David [2 ]
机构：
[1] Royal Natl Orthopaed Hosp, Sarcoma Unit, London HA7 4LP, England
[2] UCL, Inst Orthopaed & Musculoskeletal Sci, Royal Natl Orthopaed Hosp, London HA7 4LP, England
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2013年 / 8卷 / 03期
关键词：
Biomaterials; orthopaedics; scaffolds; tissue engineering; MARROW STROMAL CELLS; AUTOLOGOUS CHONDROCYTE IMPLANTATION; CALCIUM-PHOSPHATE BIOCERAMICS; BETA-TRICALCIUM PHOSPHATE; MESENCHYMAL STEM-CELLS; FULL-THICKNESS DEFECTS; PLATELET-RICH PLASMA; IN-VITRO; OSTEOCHONDRAL DEFECTS; MECHANICAL-PROPERTIES;
D O I：
10.2174/1574888X11308030002
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In orthopaedic tissue engineering, scaffolds may be viewed as a substitute for the extra-cellular matrix. Factors that contribute to an ideal scaffold include strength, degradation rate, porosity, surface property and immune response. Scaffolds may be composed of natural or synthetic polymers, each with its advantages and disadvantages. Composite scaffolds are utilised to alleviate the inherent issues with natural polymers whilst maintaining its benefits as well. This article reviews biomaterials and scaffolds in orthopaedic tissue engineering and covers clinical applications of scaffolds with particular emphasis on bone and cartilage tissue engineering.
引用
收藏
页码：185 / 191
页数：7
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