Genetics of Common, Complex Coronary Artery Disease

被引：157

作者：

Musunuru, Kiran ^{[1
,2
]}

Kathiresan, Sekar ^{[3
,4
,5
]}

机构：

[1] Univ Penn, Dept Med, Cardiovasc Inst, Div Cardiovasc Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Genet, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Broad Inst, Cambridge, MA 02142 USA

[4] Massachusetts Gen Hosp, Ctr Genom Med & Cardiovasc Res Ctr, Boston, MA 02114 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

来源：

CELL | 2019年 / 177卷 / 01期

关键词：

OF-FUNCTION MUTATIONS; CARDIOVASCULAR RISK LOCUS; GENOME-WIDE ASSOCIATION; SUBTILISIN/KEXIN TYPE 9; HEART-DISEASE; MYOCARDIAL INFARCTION; HUMAN HEPATOCYTES; PCSK9; VARIANTS; CHOLESTEROL;

D O I：

10.1016/j.cell.2019.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coronary artery disease represents the leading cause of death worldwide, sparing no nation, ethnicity, or economic stratum. Coronary artery disease is partly heritable. While enormous effort has been devoted to understanding the genetic basis of coronary artery disease and other common, complex cardiovascular diseases, key challenges have emerged in gene discovery, in understanding how DNA variants connect to function, and in translation of genetics to the clinic. We discuss these challenges as well as promising opportunities to bring the work closer to fruition.

引用

页码：132 / 145

页数：14

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