Toxic-Inflammatory Effects of Prostoglandin Analogs on the Ocular Surface

Purpose: To investigate the toxic-inflammatory effects of prostaglandin analogs on the ocular surface. Materials and methods: Twenty-three rats were divided into four groups. Bimatoprost 0.03% (I), latanoprost 0.005% (II), and travoprost 0.004% (III) were applied during 6 months; a control group (IV) received no treatment. Dysplasia and keratinization were evaluated on the ocular surface. In the subepithelial area, the number of lymphocytes and mast cells were counted morphologically, and collagen staining densities were compared subjectively in groups. Results: The ratio of keratinization was 3/12 and 1/10, in groups I and II. The lymphocyte cell counts were 1.4 +/- 0.19, 2.2 +/- 0.39, 2.27 +/- 0.33, and 1.87 +/- 0.35 (p>.05). The mast cell counts were 2.58 +/- 0.5, 5.4 +/- 1.1, 5.7 +/- 0.58, and 3.0 +/- 0.59. They were significantly higher in groups II and III than in group I (p<.05). Mean collagen density scores were 1.00 +/- 0.85, 2.00 +/- 0.00, and 1,73 +/- 0.70. Group II and III scores were higher than group I scores (p<.05). Conclusion: Latanoprost and travoprost seem to have more toxic-inflammatory effects on the ocular surface than bimatoprost.