Methylenetetrahydrofolate reductase gene polymorphisms association with the risk of follicular lymphoma: a meta-analysis

被引:4
|
作者
Xu, Jing-Yan [1 ]
Sun, Yun-Yu [2 ]
Zhou, Min [1 ]
Wang, Jing [1 ]
Zhang, Qi-Guo [1 ]
Xu, Xi-Hui [1 ]
Zeng, Hui [1 ]
Ouyang, Jian [1 ]
机构
[1] Nanjing Univ Chinese Med, Clin Coll Tradit Chinese & Western Med, Dept Hematol, Nanjing Drum Tower Hosp, Nanjing 210008, Peoples R China
[2] Southeast Univ, Affiliated Zhong Da Hosp, Dept Hematol, Nanjing 210009, Peoples R China
关键词
MTHFR polymorphisms; Follicular lymphoma; Meta-analysis; NON-HODGKIN-LYMPHOMA; FOLATE-METABOLIZING GENES; ONE-CARBON METABOLISM; DNA; SUSCEPTIBILITY; DISEASE; CANCER; DEFICIENCY; MUTATION;
D O I
10.1007/s13277-013-0670-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To date, case-control studies on the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and follicular lymphoma have provided controversial results. To clarify the effect of MTHFR polymorphisms on the risk of follicular lymphoma, a meta-analysis of all case-control studies was performed. The fixed effects and random effects model showed that the C677T polymorphism was associated with a risk of follicular lymphoma among Caucasian populations, and A1298C polymorphism was associated with a risk of follicular lymphoma among Asian populations. Our pooled data suggest evidence for a major role of MTHFR polymorphisms in the carcinogenesis of follicular lymphoma.
引用
收藏
页码:1467 / 1471
页数:5
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