Effects of β1-adrenoceptor polymorphisms on right atrial β-adrenoceptor density and responsiveness in patients with coronary artery disease treated with metoprolol

被引：0
|
作者：
Leineweber, K [1 ]
Rohe, P [1 ]
Bogedain, P [1 ]
Wolf, C [1 ]
Jakob, HG [1 ]
Brodde, OE [1 ]
机构：
[1] Univ Essen Gesamthsch, Inst Pathophysiol, D-4300 Essen, Germany
来源：
Cardio-Visions 2004: JUNGE EXZELLENZE IN DER KARDIOVASKULAREN FORSCHUNG | 2005年
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D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Here we report that the single nucleotide polymorphisms at position 49 (serine (Ser)-> glycine (Gly)) and 389 (arginine (Arg)-> Gly) in the beta(1)-adrenoceptor (PAR.) influences in right atria obtained from patients with coronary artery disease and undergoing coronary bypass grafting PAR density (Gly49 > Ser49) and the responsiveness to catecholamines on hemodynamic parameters like heart rate (HR) and blood pressure in vivo (Arg389 > Gly389) post bypass grafting.
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页码：163 / 165
页数：3
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