Intra-arterial tissue plasminogen activator and abciximab in patients with acute basilar artery occlusion

被引：2

作者：

Chiti, A. ^{[1
]}

Gialdini, G. ^{[1
]}

Terni, E. ^{[1
]}

Giannini, N. ^{[1
]}

Gennaro, M. ^{[1
]}

Lazzarotti, G. A. ^{[2
]}

Puglioli, M. ^{[2
]}

Orlandi, G. ^{[1
]}

Bonuccelli, U. ^{[1
]}

机构：

[1] Univ Pisa IT, Dept Clin & Expt Med, Div Neurol, Pisa, Italy

[2] Azienda Osped Univ Pisana Pisa IT, Unit Neuroradiol, Pisa, Italy

来源：

NEUROLOGICAL SCIENCES | 2013年 / 34卷 / 10期

关键词：

Vertebro-basilar stroke; Basilar occlusion; Intra-arterial thrombolysis; Cerebral angiography; Recanalisation; Vertebral dissection; THROMBOLYSIS; OUTCOMES; STROKE;

D O I：

10.1007/s10072-013-1465-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Acute basilar artery occlusion has a poor prognosis and best treatment has not been assessed yet; as for intra-arterial treatment, no "gold standard" exists. We evaluated a series of ten patients treated with intra-arterial combination of recombinant tissue plasminogen activator (rtPA) and abciximab. Partial/complete recanalisation was achieved in all patients and good outcome (1 month Modified Rankin Scale 0-2) in eight cases, while one patient had symptomatic intracranial haemorrhage and died. Such outcome appears significantly better if compared with the results of Basilar Artery International Cooperation Study, suggesting that intra-arterial administration of rtPA and abciximab may be a promising option in patients with acute basilar artery occlusion undergoing endovascular treatment.

引用

页码：1871 / 1873

页数：3

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[1] Intra-arterial tissue plasminogen activator and abciximab in patients with acute basilar artery occlusion
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G. Gialdini
E. Terni
N. Giannini
M. Gennaro
G. A. Lazzarotti
M. Puglioli
G. Orlandi
U. Bonuccelli
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