A synthesis of novel N-sulfonylated β-amino acids

被引：10
|
作者：
Freitag, D [1 ]
Metz, P [1 ]
机构：
[1] Tech Univ Dresden, Inst Organ Chem, D-01069 Dresden, Germany
来源：
TETRAHEDRON | 2006年 / 62卷 / 08期
关键词：
beta-amino acids; gamma-sultams; sulfonyl imines; sulfonamides; allylation; oxidative cleavage;
D O I：
10.1016/j.tet.2005.11.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel N-sulfonyl beta-amino acids were efficiently prepared in a seven-step synthesis starting from Boc protected methanesulfonamide and terminal epoxides. A zinc-mediated allylation of cyclic N-sulfonyl imines readily derived from these building blocks served as a key operation of this sequence. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1799 / 1805
页数：7
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