Terahertz time-domain spectroscopy of chondroitin sulfate

被引：12
|
作者：
Shi, Changcheng [1 ,2 ]
Ma, Yuting [2 ,3 ]
Zhang, Jin [2 ,3 ]
Wei, Dongshan [2 ]
Wang, Huabin [2 ]
Peng, Xiaoyu [2 ]
Tang, Mingjie [2 ]
Yan, Shihan [2 ]
Zu, Guokun [1 ]
Du, Chunlei [2 ]
Cui, Hongliang [2 ,3 ]
机构：
[1] Chinese Acad Sci, Ningbo Inst Ind Technol, Cixi Inst Biomed Engn, 1219 Zhongguan West Rd, Ningbo 315201, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Terahertz Technol, Chongqing Key Lab Multiscale Mfg Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China
[3] Jilin Univ, Coll Instrumentat & Elect Engn, 2699 Qianjin Ave, Changchun 130061, Jilin, Peoples R China
来源：
BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 03期
关键词：
KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; SAMPLE THICKNESS; DOUBLE-BLIND; THZ; SCATTERING; PLACEBO; SPECTRA;
D O I：
10.1364/BOE.9.001350
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Chondroitin sulfate (CS), derived from cartilage tissues, is an important type of biomacromolecule. In this paper, the terahertz time-domain spectroscopy (THz-TDS) was investigated as a potential method for content detection of CS. With the increase of the CS content, the THz absorption coefficients of the CS/polyethylene mixed samples linearly increase. The refractive indices of the mixed samples also increase when the CS content increases. The extinction coefficient of CS demonstrates the THz frequency dependence to be approximately the power of 1.4, which can be explained by the effects of CS granular solids on THz scattering. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码：1350 / 1359
页数：10
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