Recent Advances in Clinical Applications of Circulating Cell-free DNA Integrity

被引：31

作者：

Yu, Jiajia ^{[1
]}

Gu, Guohao ^{[2
]}

Ju, Shaoqing ^{[1
,3
,4
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Lab Med Ctr, Nantong, Jiangsu, Peoples R China

[2] Suzhou Univ, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China

[3] Nantong Univ, Affiliated Hosp, Surg Comprehens Lab, Nantong, Jiangsu, Peoples R China

[4] Nantong Univ, Sch Publ Hlth, Nantong, Jiangsu, Peoples R China

来源：

LABMEDICINE | 2014年 / 45卷 / 01期

关键词：

Circulating cell-free DNA (ccf-DNA); DNA integrity; diagnosis of cancer; monitoring the response to therapy; prenatal diagnosis;

D O I：

10.1309/LMKKOX6UJZQGW0EA

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Circulating DNA is an emerging biomarker in various types of cancer. It is generally believed that DNA released from apoptotic cells is uniformly truncated to small DNA fragments with 185-200 base pair (bp), whereas DNA produced by malignant cells varies in size (most of these are longer DNA fragments). Recently, the application of circulating DNA integrity indexes, represented by the ratio of the longer DNA fragments concentration to the shorter ones, has been reported in different cancers. This review will summarize the recently reported assays for detection of the circulating cell-free DNA (ccf-DNA) integrity and their clinical utility.

引用

页码：6 / 11

页数：6

共 50 条

[1] Potential clinical applications of circulating cell-free DNA in ovarian cancer patients
Barbosa, Ana
Peixoto, Ana
Pinto, Pedro
Pinheiro, Manuela
Teixeira, Manuel R.
EXPERT REVIEWS IN MOLECULAR MEDICINE, 2018, 20 : e6
[2] Recent advances in circulating tumor cells and cell-free DNA in metastatic prostate cancer: a review
Parimi, Sunil
Ko, Jenny J.
EXPERT REVIEW OF ANTICANCER THERAPY, 2017, 17 (10) : 939 - 949
[3] Quantifying circulating cell-free DNA as clinical biomarker
Romain, M.
Dache, Z. A. A.
Otandault, A.
Tanos, R.
Pastor, B.
Sanchez, C.
Azzi, J.
Tousch, G.
Azan, S.
Mollevi, C.
Thezenas, S.
Blache, P.
Thierry, A. R.
ANNALS OF ONCOLOGY, 2018, 29
[4] circulating cell-free DNA (CFDNA) after allogeneic cell transplantation: Characteristics and clinical applications
Waterhouse, Miguel
Duque-Afonso, Jesus
Pfeifer, Dietmar
Duyster, Justus
Bertz, Hartmut
Finke, Juergen
BONE MARROW TRANSPLANTATION, 2019, 54 : 481 - 482
[5] Circulating Cell-Free DNA and DNA Integrity as Molecular Diagnostic Tools in Hepatocellular Carcinoma
Elzehery, Rasha
Effat, Narmin
El Farahaty, Reham
Farag, Raghda Elsayed
Abo-Hashem, Ekbal M.
Elhelaly, Rania
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2022, 158 (02) : 254 - 262
[6] Prediction of conventional renal cell cancer by integrity of cell-free circulating DNA in serum
Gang Feng
Li Guorong
Zhao An
Anne, Gentil-Perret
Christian, Genin
Jacques, Tostain
BULLETIN DU CANCER, 2009, 96 : S10 - S10
[7] Increased integrity of circulating cell-free DNA in plasma of patients with acute leukemia
Gao, Yu-Jie
He, Yu-Juan
Yang, Zai-Lin
Shao, Hui-Yuan
Zuo, Yan
Bai, Yao
Chen, Hui
Chen, Xian-Chun
Qin, Feng-Xian
Tan, Shi
Wang, Jian
Wang, Li
Zhang, Ling
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2010, 48 (11) : 1651 - 1656
[8] Circulating cell-free DNA and its integrity as a prognostic marker for breast cancer
Iqbal, Sobuhi
Vishnubhatla, Sreenivas
Raina, Vinod
Sharma, Surabhi
Gogia, Ajay
Deo, Suryanarayana S. V.
Mathur, Sandeep
Shukla, Nutan Kumar
SPRINGERPLUS, 2015, 4
[9] Circulating cell-free DNA and its clinical utility in cancer
Salviano-Silva, Amanda
Maire, Cecile L.
Lamszus, Katrin
Ricklefs, Franz L.
JOURNAL OF LABORATORY MEDICINE, 2022, 46 (04) : 265 - 272
[10] Clinical correlates of circulating cell-free DNA tumor fraction
Bredno, Joerg
Lipson, Jafi
Venn, Oliver
Aravanis, Alexander M.
Jamshidi, Arash
PLOS ONE, 2021, 16 (08):

← 1 2 3 4 5 →