HO-3867-induced apoptosis in hypoxic ovarian cancer cells occurs via ubiquitin-dependent degradation of signal transducer and activator of transcription 3 (STAT3)

被引:0
|
作者
McCann, Georgia [1 ]
Cohn, David [1 ]
Hideg, Kalman [2 ]
Kuppusamy, Periannan [1 ]
Karuppaiyah, Selvendiran [1 ]
机构
[1] Ohio State Univ, Columbus, OH 43210 USA
[2] Univ Pecs, Inst Organ & Med Chem, Pecs, Hungary
关键词
D O I
10.1158/1538-7445.AM2011-2059
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2059
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Activation of signal transducer and activator of transcription 3 (STAT3) in ovarian cancer: The hypoxic implications
    McCann, G.
    Tierney, B.
    Sudhakar, M.
    Cohn, D.
    Karuppaiyah, S.
    GYNECOLOGIC ONCOLOGY, 2012, 125 : S144 - S145
  • [2] Activation of Signal Transducer and Activator of Transcription 3 (STAT3) in ovarian cancer: The hypoxic implications
    McCann, Georgia A.
    Naidu, Shan
    Tierney, Brent J.
    Sudhakar, Meryl
    Cohn, David E.
    Selvendiran, Karuppaiyah
    CANCER RESEARCH, 2012, 72
  • [3] Hypoxia-mediated activation of signal transducer and activator of transcription 3 (STAT3) in ovarian cancer: A novel therapeutic strategy using HO-3867, a STAT3 inhibitor
    McCann, G.
    Selvendiran, K.
    Hideg, K.
    Cohn, D.
    Kuppusamy, P.
    GYNECOLOGIC ONCOLOGY, 2011, 121 (01) : S25 - S25
  • [4] Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
    Barton, BE
    Karras, JG
    Murphy, TF
    Barton, A
    Huang, HFS
    MOLECULAR CANCER THERAPEUTICS, 2004, 3 (01) : 11 - 20
  • [5] Activated signal transducer and activator of transcription 3 (STAT3) in primary breast cancer
    Nilsson, Linn
    Sanden, Emma
    Khazaei, Somayeh
    Tryggadottir, Helga
    Nodin, Bjorn
    Jirstrom, Karin
    Borgquist, Signe
    Isaksson, Karolin
    Jernstrom, Helena
    BREAST CANCER RESEARCH AND TREATMENT, 2020, 180 (02) : 549 - 549
  • [6] HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells
    Tierney, Brent J.
    McCann, Georgia A.
    Cohn, David E.
    Eisenhauer, Eric
    Sudhakar, Meryl
    Kuppusamy, Periannan
    Hideg, Kalman
    Selvendiran, Karuppaiyah
    CANCER BIOLOGY & THERAPY, 2012, 13 (09) : 766 - 775
  • [7] TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity
    Schick, N
    Oakeley, EJ
    Hynes, NE
    Badache, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (37) : 38787 - 38796
  • [8] Eupalinolide J Inhibits Cancer Metastasis by Promoting STAT3 Ubiquitin-Dependent Degradation
    Hu, Hongtao
    Bai, Haoyang
    Huang, Lili
    Yang, Bo
    Zhao, Huajun
    MOLECULES, 2023, 28 (07):
  • [9] Induction of apoptosis following inhibition of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors
    Paner, GP
    Silberman, S
    Hartman, G
    Alkan, S
    LABORATORY INVESTIGATION, 2003, 83 (01) : 131A - 131A
  • [10] Induction of apoptosis following inhibition of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors
    Paner, GP
    Silberman, S
    Hartman, G
    Alkan, S
    MODERN PATHOLOGY, 2003, 16 (01) : 131A - 131A