Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide®)

被引：0
|
作者：
Chalupová, D [1 ]
Holy, A [1 ]
机构：
[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague, Czech Republic
来源：
CHEMISTRY OF NUCLEIC ACID COMPONENTS | 2005年 / 7卷
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide (R)) has a unique profile among the antiviral agents in that it is active against a much broader spectrum of DNA viruses than any other antiviral agent. The activity spectrum of HPMPC encompasses herpes-, adeno-, polyoma-, papilloma and poxviruses. As the systemic drug Viread (TM) it is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity.
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页码：387 / 388
页数：2
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