Large granular lymphocytes (LGL) following non-myeloablative allogeneic bone marrow transplantation: a case report

被引：13
|
作者：
Mohty, M
Faucher, C
Gaugler, B
Vey, N
Sainty, D
Arnoulet, C
Mozziconacci, MJ
Isnardon, D
Gastaut, JA
Maraninchi, D
Olive, D
Blaise, D
机构：
[1] Inst J Paoli I Calmettes, Unite Transplantat & Therapie Cellulaire, F-13273 Marseille, France
[2] Univ Mediterranee, Inst J Paoli I Calmettes, Lab Immunol Tumeurs, Marseille, France
[3] INSERM, U119, F-13258 Marseille, France
[4] Univ Mediterranee, Inst J Paoli I Calmettes, Dept Hematol, Marseille, France
来源：
BONE MARROW TRANSPLANTATION | 2001年 / 28卷 / 12期
关键词：
LGL; anti-tumor activity; allo-BMT; non-myeloablative; GVT;
D O I：
10.1038/sj.bmt.1703308
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.
引用
收藏
页码：1157 / 1160
页数：4
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