The DNA methylation machinery as a target for anticancer therapy

被引：75
|
作者：
Szyf, M
机构：
[1] Dept. of Pharmacol. and Therapeutics, McGill University, Montreal, Que. PQ H3G 1Y6
来源：
PHARMACOLOGY & THERAPEUTICS | 1996年 / 70卷 / 01期
关键词：
DNA methylation; demethylation; de novo methylation; epigenetic modification; anticancer agents; 5-deoxyazacytidine;
D O I：
10.1016/0163-7258(96)00002-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
DNA methylation is now recognized as an important mechanism regulating different functions of the genome; gene expression, replication, and cancer, Different factors control the formation and maintenance of DNA methylation patterns. The level of activity of DNA methyltransferase (MeTase) is one factor. Recent data suggest that some oncogenic pathways can induce DNA MeTase expression, that DNA MeTase activity is elevated in cancer, and that inhibition of DNA MeTase can reverse the transformed state. What are the pharmacological consequences of our current understanding of DNA methylation patterns formation! This review will discuss the possibility that DNA MeTase inhibitors can serve as important pharmacological and therapeutic tools in cancer and other genetic diseases.
引用
收藏
页码：1 / 37
页数：37
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