A new cycloartane triterpene and other phytoconstituents from the aerial parts ofEuphorbia dendroides

New cycloartane-type triterpene 23 R/S-3 beta-hydroxycycloart-24-ene-23-methyl ether1a,b(as an C-23 epimeric mixture), along with ten known compounds, including 1 steroid, 3 fatty acids and 6 triterpenoids were isolated from the aerial parts ofEuphorbia dendroidesL. (Euphorbiaceae). The known compounds (2-11) were identified using 1 D & 2 D-NMR spectra and by comparison with data reported in the literature as well as using GC-MS for the isolated fatty acids. The new compound1 (a,b)was elucidated by comprehensive 1 D & 2 D NMR experiments as well as LR & HR-FAB-MS. In addition, the isolated cycloartane-type triterpenoids have been tested forin vitrocytotoxicity against different cell lines. The new compound1 (a,b)exhibited good to weak selective cytotoxic activities against HepG2, Huh-7, KLM-1, 1321N1 and HeLa cell lines with IC(50)values of 20.67 +/- 0.72, 16.24 +/- 0.53, 22.59 +/- 0.94, 25.99 +/- 0.31 and 40.50 +/- 3.14 mu M, respectively.