Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging

被引：15

作者：

Jalilian, Amir R. ^{[1
]}

Rostampour, Nima ^{[2
]}

Rowshanfarzad, Pejman ^{[1
]}

Shafaii, Kamaleddin ^{[1
]}

Kamali-Dehghan, Mohsen ^{[1
]}

Akhlaghi, Mehdi ^{[1
]}

机构：

[1] AMIRS, Nucl Med Res Grp, Karaj, Japan

[2] Univ Med Sci Hamadan, Sch Med, Dept Med Phys, Hamadan, Iran

来源：

ACTA PHARMACEUTICA | 2009年 / 59卷 / 01期

关键词：

radiopharmaceuticals; copper-61; Cu-61]ATSM hypoxia; positron emission tomography; fibrosarcoma; imaging; PERFORMANCE; GENERATOR; CANCER; LUNG;

D O I：

10.2478/v10007-009-0008-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[Cu-61] diacetyl-bis(N-4-methylthiosemicarbazone) ([Cu-61]ATSM) was prepared using in house-made diacetyl-bis(N-4-methylthiosemicarbazone) (ATSM) ligand and [Cu-61]CuCl2 produced via the Zn-nat(p, x)Cu-61 (180 mu A proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [Cu-61]ATSM radiochemical purity was > 98 %, as shown by HPLC and RTLC methods. [Cu-61]ATSM was administered into normal and tumor bearing rodents for up to 210 minutes, followed by biodistribution and co-incidence imaging studies. Significant tumor/non-tumor accumulation was observed either by animal sacrification or imaging. [Cu-61]ATSM is a positron emission tomography (PET) radiotracer for tumor hypoxia imaging.

引用

页码：45 / 55

页数：11

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