Chemical fate and changes in mutagenic activity of antibiotics nitrofurazone and furazolidone during aqueous chlorination

被引：12

作者：

Nakamura, Hitomi ^{[1
]}

Kawakami, Tsuyoshi ^{[1
]}

Niino, Tatsuhiro ^{[2
]}

Takahashi, Yasuo ^{[1
]}

Onodera, Sukeo ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Pharmaceut Sci, Chiba 2788510, Japan

[2] Mitsubishi Chem Safety Inst Ltd, Aoba Ku, Yokohama, Kanagawa 2270033, Japan

来源：

JOURNAL OF TOXICOLOGICAL SCIENCES | 2008年 / 33卷 / 05期

关键词：

Nitrofurazone; Furazolidone; Water chlorination; Mutagenicity;

D O I：

10.2131/jts.33.621

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Reactions of nitrofuran antibiotics (nitrofurazone (NFZ) and frazolidone (FZD)) with hypochlorite in aqueous Solution were investigated under the conditions that Simulate wastewater disinfection. The chlorination by products were determined by high performance liquid chromatography. At the levels of 5 mu M, NFZ reacted rapidly with free chlorine in neutral pH (7.0), while the FZD-hypochlorite reaction was reasonably slow under the same pH. Nevertheless, the strong mutagenic parents disappeared completely after the hypochlorite reactions, and the chlorination by products were observed to exert a weak mutagenic effect oil Salmonella typhimurium TA 100 Without S9-mix. The extent of the reactions depended oil the chlorine dose, solution PH and Compound Structures.

引用

页码：621 / 629

页数：9

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