Stereoselective synthesis of quaternary proline analogues

被引：103
|
作者：
Calaza, M. Isabel [1 ]
Cativiela, Carlos [1 ]
机构：
[1] Univ Zaragoza, Dept Quim Organ, Inst Ciencia Mat Aragon, CSIC, E-50009 Zaragoza, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 20期
关键词：
alpha; alpha-disubstituted amino acids; constrained amino acids; alpha-substituted prolines; diastercoselectivity; enantio selectivity;
D O I：
10.1002/ejoc.200800225
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This review describes available methods for the diastereoselective and asymmetric synthesis of quaternary prolines. The focus is on the preparation of alpha-functionalized prolines in which the pyrrolidine moiety is not embedded in a polycyclic frame. The diverse synthetic approaches are classified according to the bond that is formed to complete the quaternary skeleton. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：3427 / 3448
页数：22
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