Muscle biopsy features in critical ill patients with 2009 influenza A (H1N1) virus infection

被引:4
|
作者
Lorenzoni, Paulo Jose [1 ]
Kamoi Kay, Claudia Suemi [1 ]
Scola, Rosana Herminia [1 ]
Carraro Junior, Hipolito [1 ]
Werneck, Lineu Cesar [1 ]
机构
[1] Univ Fed Paran UFPR, Hosp Clin, Dept Internal Med, Div Neurol,Neuromuscular Disorders Serv, Curitiba, Parana, Brazil
关键词
Influenza A virus; H1N1; subtype; creatine kinase; muscle biopsy; A(H1N1);
D O I
10.1590/S0004-282X2012000500004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Higher serum creatine kinase (CK) levels in critically ill patients with a confirmed 2009 influenza A (H1N1) infection suggests a possible relationship between the H1N1 virus and muscle tissue. However, there have been no reports with an emphasis on muscle biopsies for patients infected with the H1N1 virus. The objective of this study was to investigate the histological characteristics of the muscle biopsies from critically ill patients with confirmed 2009 H1N1 infections. A series of ten patients with confirmed 2009 H1N1 infection, who presented increased serum CK levels, was analyzed. Histological study found small histochemical alterations in muscles fibers (mainly in NADH, SDH, COX, myophosphorylase, adenylate deaminase and PAS stains), and no histological changes were compatible with inflammatory myopathy. Although our critically ill patients had elevated CK levels, they exhibited few histological/histochemical abnormalities in their muscle biopsy samples; however, those alterations could be consistent with metabolic dysfunction associated with influenza H1N1 infection.
引用
收藏
页码:325 / 329
页数:5
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