Modular design of nanobody-drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent

被引：39

作者：

Huang, Hai ^{[1
]}

Wu, Tiantian ^{[1
]}

Shi, Hongdong ^{[1
]}

Wu, Yun ^{[2
]}

Yang, Hongyi ^{[2
]}

Zhong, Kai ^{[2
]}

Wang, Yucai ^{[3
,4
]}

Liu, Yangzhong ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

[2] Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

[4] Univ Sci & Technol China, Med Ctr, Hefei 230027, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 35期

基金：

美国国家科学基金会; 国家重点研发计划;

关键词：

CISPLATIN; THERAPY;

D O I：

10.1039/c9cc01391a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multifunctional nanobody-drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin. The Gd-binding domain enables the in situ detection of the drug distribution in vivo.

引用

页码：5175 / 5178

页数：4

共 11 条

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