Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy

被引：85

作者：

Beumer, Jan H. ^{[1
,2
,3
]}

Chu, Edward ^{[1
,3
]}

Allegra, Carmen ^{[4
]}

Tanigawara, Yusuke ^{[5
]}

Milano, Gerard ^{[6
]}

Diasio, Robert ^{[7
,8
]}

Kim, Tae Won ^{[9
]}

Mathijssen, Ron H. ^{[10
]}

Zhang, Li ^{[11
]}

Arnold, Dirk ^{[12
]}

Muneoka, Katsuki ^{[13
]}

Boku, Narikazu ^{[14
]}

Joerger, Markus ^{[15
]}

机构：

[1] UPMC Hillman Canc Ctr, Canc Therapeut Program, Pittsburgh, PA 15232 USA

[2] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15213 USA

[4] Univ Florida, Gainesville, FL USA

[5] Keio Univ, Sch Med, Dept Clin Pharmacokinet & Pharmacodynam, Tokyo, Japan

[6] Ctr Antoine Lacassagne, Oncopharmacol Unit, Nice, France

[7] Mayo Clin, Canc Ctr, Dev Therapeut Program, Rochester, MN USA

[8] Mayo Clin, Sch Med, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

[9] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea

[10] Erasmus Univ, Med Ctr, Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands

[11] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Med Oncol,Canc Ctr, Guangzhou, Guangdong, Peoples R China

[12] Asklepios Tumorzentrum Hamburg, AK Altona, Dept Oncol, Hamburg, Germany

[13] Niitsu Med Ctr Hosp, Div Oncol Ctr, Niigata, Japan

[14] Natl Canc Ctr, Dept Gastrointestinal Med Oncol, Chuo Ku, Tokyo, Japan

[15] Cantonal Hosp, Dept Med Oncol & Hematol, St Gallen, Switzerland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2019年 / 105卷 / 03期

基金：

美国国家卫生研究院;

关键词：

DIHYDROPYRIMIDINE DEHYDROGENASE-ACTIVITY; METASTATIC COLORECTAL-CANCER; FLUOROURACIL DOSE ADJUSTMENT; CONTINUOUS-INFUSION; PHASE-II; CIRCADIAN VARIATION; URIDINE TRIACETATE; DEFICIENT PATIENTS; MONONUCLEAR-CELLS; RANDOMIZED-TRIAL;

D O I：

10.1002/cpt.1124

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5-Fluorouracil (5-FU) is dosed by body surface area, a practice unable to reduce the interindividual variability in exposure. Endorsed by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), we evaluated clinical evidence and strongly recommend TDM for the management of 5-FU therapy in patients with colorectal or head-and-neck cancer receiving common 5-FU regimens. Our systematic methodology provides a framework to evaluate published evidence in support of TDM recommendations in oncology.

引用

页码：598 / 613

页数：16

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