Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence

被引：13
|
作者：
Rohde, Manfred [2 ]
Talay, Susanne R. [2 ]
Rasmussen, Magnus [1 ]
机构：
[1] Lund Univ, Dept Clin Sci, Div Infect Med, S-22184 Lund, Sweden
[2] Helmholtz Ctr Infect Res, Dept Med Microbiol, Braunschweig, Germany
来源：
MICROBES AND INFECTION | 2012年 / 14卷 / 04期
关键词：
Recurrent bacteremia; Intravascular persistence; Internalization; Platelet aggregation; GROUP-A STREPTOCOCCI; ENTEROCOCCUS-FAECALIS; BINDING PROTEIN; GROUP-C; BACTEREMIA; PYOGENES; ALPHA(2)-MACROGLOBULIN; IDENTIFICATION; EPIDEMIOLOGY; ENDOCARDITIS;
D O I：
10.1016/j.micinf.2011.10.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：329 / 334
页数：6
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