Efficacy of memantine in Parkinson's disease with dementia

被引：0
|
作者：
Levin, O. S. [1 ]
Batukaeva, L. A. [1 ]
机构：
[1] Russian Med Acad Postgrad Educ, Extra Pyramid Dis Ctr, Chair Neurol, Moscow, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2008年 / 108卷 / 12期
关键词：
Parkinson's disease; dementia; treatment; memantine (akatinol-memantine);
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Memantine M was used in the treatment of patients with Parkinson's disease (PD) with dementia. The drug was prescribed to 15 patients at first in a single dosage of 5 mg daily for one week, then the dosage was increased to 10 mg daily (one week), after to 15 mg daily (one week) and from the 4(th) week - to 20mg daily. Patients of the control group did not receive the drug. Efficacy and safety of M were assessed clinically and with a battery of widespread scales (UPDRS, MMSE, CGI etc), neuropsychological tests and the quality of life scale (PDQ-8). The study showed the ability of M to cause a stable improvement of mental state and its good tolerability. The efficacy of M in the cases studied was comparable with that in Alzheimer's disease.
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页码：16 / 23
页数：8
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