Genetic and Neurophysiological Correlates of the Age of Onset of Alcohol Use Disorders in Adolescents and Young Adults

被引：20

作者：

Chorlian, David B. ^{[1
]}

Rangaswamy, Madhavi ^{[1
]}

Manz, Niklas ^{[1
]}

Wang, Jen-Chyong ^{[2
]}

Dick, Danielle ^{[3
]}

Almasy, Laura ^{[4
]}

Bauer, Lance ^{[5
]}

Bucholz, Kathleen ^{[2
]}

Foroud, Tatiana ^{[6
]}

Hesselbrock, Victor ^{[5
]}

Kang, Sun J. ^{[1
]}

Kramer, John ^{[7
]}

Kuperman, Sam ^{[7
]}

Nurnberger, John, Jr. ^{[8
]}

Rice, John ^{[2
]}

Schuckit, Marc ^{[9
]}

Tischfield, Jay ^{[10
]}

Edenberg, Howard J. ^{[11
]}

Goate, Alison ^{[2
]}

Bierut, Laura ^{[2
]}

Porjesz, Bernice ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Henri Begleiter Neurodynam Lab, Dept Psychiat & Behav Sci, Brooklyn, NY 11203 USA

[2] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[3] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA

[4] Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA

[5] Univ Connecticut, Ctr Hlth, Dept Psychiat, Farmington, CT 06032 USA

[6] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

[7] Univ Iowa, Coll Med, Dept Psychiat, Iowa City, IA 52242 USA

[8] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[9] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[10] Rutgers State Univ, Dept Genet, Piscataway, NJ USA

[11] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

来源：

BEHAVIOR GENETICS | 2013年 / 43卷 / 05期

关键词：

Alcoholism; CHRM2; Survival analysis; ERO; Genetics; Adolescents; TIME SURVIVAL ANALYSIS; SUBSTANCE USE; EXTERNALIZING PSYCHOPATHOLOGY; ENVIRONMENTAL-INFLUENCES; CHOLINERGIC MODULATION; DRUG-DEPENDENCE; DRINKING ONSET; P300; AMPLITUDE; CHRM2; GENE; BEHAVIOR;

D O I：

10.1007/s10519-013-9604-z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2,938 adolescents and young adults ages 12-25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.

引用

页码：386 / 401

页数：16

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