Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers

被引:3
|
作者
Eshkoor, Sima Ataollahi [1 ,2 ]
Ismail, Patimah [2 ]
Abd Rahman, Sabariah [2 ]
Adon, Mohd Yusoff [3 ]
Devan, R. Vasu [4 ]
机构
[1] Univ Putra Malaysia, Inst Gerontol, Serdang, Malaysia
[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang, Malaysia
[3] Minist Hlth Malaysia, Inst Med Res, Kuala Lumpur, Malaysia
[4] Monash Univ, Sch Sci, Bandar Sunway, Malaysia
关键词
Aging; comet assay; CYP2E1; polymorphism; micronuclei; occupational exposure; CYTOGENETIC DAMAGE; PERIPHERAL-BLOOD; GENETIC-DAMAGE; GENOTOXIC RISK; LUNG-CANCER; SUSCEPTIBILITY; EXPOSURE; GSTT1; MICRONUCLEI; LYMPHOCYTES;
D O I
10.3109/15376516.2012.743637
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Aging is attributed to both genetic and environmental factors. Occupational exposure is one of the environmental factors with potential genotoxic effects. Researchers try to determine factors involved in genetic damages at hazards exposure that could accelerate aging. Cytochrome P450 2E1 (CYP2E1) gene contributes in activation and detoxification of the environmental hazards. This polymorphism plays an important role in susceptibility of inter-individuals to DNA damage at the occupational exposure. The current study evaluated the possible influence of this gene polymorphism in aging by genomic damages through the biomarkers alterations of micronuclei (MN), comet tail length and telomere length shortening at the exposure. In this study, buccal cells were collected from the oral cavity of exposed workers and non-exposed controls. The CYP2E1 genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The wild genotype significantly affected MN frequency (p = 0.007) and relative telomere length (p = 0.047) in the older group of workers. It was concluded that the interaction of gene polymorphism and exposure enhances DNA damage and accelerates aging consequently.
引用
收藏
页码:217 / 222
页数:6
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