Dimeric cinchona ammonium salts with benzophenone linkers: enantioselective phase transfer catalysts for the synthesis of α-amino acids

被引：9

作者：

Woo, Seunga ^{[1
]}

Kim, Yong-Gyun ^{[1
]}

Lim, Baegeun ^{[1
]}

Oh, Jiin ^{[1
]}

Lee, Yeonji ^{[1
]}

Gwon, Hyeri ^{[1
]}

Nahm, Keepyung ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem & Biochem, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea

来源：

RSC ADVANCES | 2018年 / 8卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

ASYMMETRIC CATALYSIS; CHIRAL POLYMERS; SCHIFF-BASE; ALKYLATION; ALKALOIDS; ENOLATE; IMINES; STATE;

D O I：

10.1039/c7ra12499f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral phase transfer catalysts of dimeric cinchona ammonium salts linked with a benzophenone bridge showed high enantioselectivity in the alpha-alkylation of a glycinate ester under mild industry-applicable conditions: 0.5 mol% PTC and near equivalents of alkyl halide. A dual function of the dimeric quinuclidiniums was proposed for the high efficiency.

引用

页码：2157 / 2160

页数：4

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