Synthesis of Chlamydocin by Chelate-Claisen Rearrangement

被引：23

作者：

Quirin, Christian ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Univ Saarland, Inst Organ Chem, D-66123 Saarbrucken, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 03期

关键词：

Ace; Chlamydocin; Cyclopeptides; Natural products; Rearrangement; Total synthesis; HOST-SPECIFIC TOXIN; PROTECTED 2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID; GAMMA; DELTA-UNSATURATED AMINO-ACIDS; CATALYZED ALLYLIC SUBSTITUTIONS; CYTOSTATIC CYCLIC TETRAPEPTIDE; HISTONE DEACETYLASE FUNCTION; HELMINTHOSPORIUM-CARBONUM; HC-TOXIN; ENANTIOSELECTIVE SYNTHESIS; CYLINDROCLADIUM-SCOPARIUM;

D O I：

10.1002/ejoc.200800890

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chelate-Claisen rearrangement of a chiral allylic ester allows the synthesis of the unusual epoxyketo amino acid Aoe found in chlamydocin, one representative of a group of peptide-based HDAc inhibitors. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：371 / 377

页数：7

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