Intra-Operative Neural Monitoring of Thyroid Surgery in a Porcine Model

被引：15

作者：

Wu, Che-Wei ^{[1
,2
,3
]}

Huang, Tzu-Yen ^{[2
]}

Chen, Hui-Chun ^{[4
]}

Chen, Hsiu-Ya ^{[5
]}

Tsai, Tsung-Yi ^{[2
]}

Chang, Pi-Ying ^{[5
]}

Lin, Yi-Chu ^{[2
]}

Tseng, Hsin-Yi ^{[2
]}

Hun, Pao-Chu ^{[6
]}

Liu, Xiaoli ^{[7
,8
]}

Sun, Hui ^{[7
,8
]}

Randolph, Gregory W. ^{[9
,10
,11
]}

Dionigi, Gianlorenzo ^{[12
]}

Chiang, Feng-Yu ^{[2
,3
]}

Lu, I-Cheng ^{[5
,13
,14
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Otorhinolaryngol, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Otorhinolaryngol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Dept Otorhinolaryngol, Fac Med, Coll Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Nursing, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Anesthesiol, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Lab Anim Ctr, Kaohsiung, Taiwan

[7] Jilin Univ, China Japan Union Hosp, Dept Thyroid & Parathyroid Surg, Changchun, Jilin, Peoples R China

[8] Jilin Univ, Jilin Prov Key Lab Surg Translat Med, Changchun, Jilin, Peoples R China

[9] Massachusetts Eye & Ear Infirm, Dept Otolaryngol, Div Thyroid & Parathyroid Endocrine Surg, 243 Charles St, Boston, MA 02114 USA

[10] Massachusetts Gen Hosp, Dept Surg, Div Surg Oncol, Boston, MA 02114 USA

[11] Harvard Med Sch, Dept Otol & Laryngol, Boston, MA 02115 USA

[12] Univ Messina, Univ Hosp G Martino, Dept Human Pathol Adulthood & Child Hood G Barres, Div Endocrine Surg, Messina, Italy

[13] Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Anesthesiol, Kaohsiung, Taiwan

[14] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Anesthesiol, Kaohsiung, Taiwan

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2019年 / 144期

关键词：

Medicine; Issue; 144; Intraoperative neural monitoring; recurrent laryngeal nerve; external branch of the superior laryngeal nerve; vagus nerve; thyroid surgery; animal study; porcine model; RECURRENT LARYNGEAL NERVE; INDUCED-NEUROMUSCULAR-BLOCKADE; VOCAL CORD PARALYSIS; ELECTROPHYSIOLOGIC CHANGES; SUGAMMADEX-ALLOWS; INJURY; STIMULATION; ROCURONIUM; ELECTROMYOGRAPHY; REVERSAL;

D O I：

10.3791/57919

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intraoperative injury to the recurrent laryngeal nerve (RLN) can cause vocal cord paralysis, which interferes with speech and can potentially interfere with breathing. In recent years, intraoperative neural monitoring (IONM) has been widely adapted as an adjunct technique to localize the RLN, detect RLN injury, and predict vocal cord function during the operations. Many studies have also used animal models to investigate new applications of IONM technology and to develop reliable strategies for preventing intraoperative RLN injury. The aim of this article is to introduce a standard protocol for using a porcine model in IONM research. The article demonstrates the procedures for inducing general anesthesia, performing tracheal intubation, and experimental design to investigate the electrophysiological characteristics of RLN injuries. Applications of this protocol can improve overall efficacy in implementing the 3R principle (replacement, reduction and refinement) in porcine IONM studies.

引用

页数：12

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