Synthesis and photodynamic therapy of mono-mannose modified perylene bisimide bridged permethyl-β-CDs

被引：14

作者：

Cao, Guo-Jing ^{[1
]}

Rong, Rui-Xue ^{[1
,2
]}

Wang, Ya-Nan ^{[1
]}

Xu, Qi ^{[1
]}

Wang, Ke-Rang ^{[1
]}

Li, Xiao-Liu ^{[1
]}

机构：

[1] Hebei Univ, Minist Educ, Key Lab Chem Biol Hebei Prov, Coll Chem & Environm Sci,Key Lab Med Chem & Mol D, Baoding 071002, Peoples R China

[2] Hebei Univ, Sch Basic Med Sci, Dept Immunol, Baoding 071002, Peoples R China

来源：

DYES AND PIGMENTS | 2017年 / 136卷

关键词：

Perylene bisimide; Photodynamic therapy; Fluorescence imaging; Cyclodextrin; Carbohydrate; SINGLET OXYGEN; IN-VITRO; CYCLODEXTRIN; PORPHYRIN; CANCER; NANOPARTICLES; APOPTOSIS; BINDING; BIS(BETA-CYCLODEXTRIN)S; PHOTOSENSITIZER;

D O I：

10.1016/j.dyepig.2016.09.006

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A mono-mannose modified perylene bisimide bridged permethyl-beta-CDs 8 was synthesized, which showed interestingly solvent-controlled chirality because of self-inclusion effect of permethyl-beta-CD. Furthermore, compound 8 as photodynamic therapy agent exhibited potent photodynamic therapy activities with the IC50 values of 3.96, 16.79, 6.62 and 5.14 mu M against MCF-7, Hela, A549 and Hep G2 cells, respectively, better than the control compound TPPS. Then the mechanism of the cell death induced by 8 was investigated by flow cytometric analysis, obvious apoptosis process was observed. Moreover, 8 as photostability molecule showed fluorescent imaging with the MCF-7 cells. 8 as a novel PDT molecule showed high pohotocytotoxicity and live cell imaging applications. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：569 / 576

页数：8