BRAFO tiered approach for benefit-risk assessment of foods

被引:44
|
作者
Hoekstra, Jeljer [2 ]
Hart, Andy [3 ]
Boobis, Alan [4 ]
Claupein, Erika [5 ]
Cockburn, Andrew [6 ]
Hunt, Alistair [7 ]
Knudsen, Ib [8 ]
Richardson, David [9 ]
Schilter, Benoit [10 ]
Schutte, Katrin [11 ]
Torgerson, Paul R. [12 ]
Verhagen, Hans [2 ]
Watzl, Bernhard [5 ]
Chiodini, Alessandro [1 ]
机构
[1] ILSI Europe, B-1200 Brussels, Belgium
[2] Natl Inst Publ Hlth & Environm RIVM, NL-3720 BA Bilthoven, Netherlands
[3] FERA, Risk Anal Team, York YO41 1LZ, N Yorkshire, England
[4] Univ London Imperial Coll Sci Technol & Med, Div Med, Fac Med, London W12 0NN, England
[5] Mission Res Inc, Fed Res Inst Nutr & Food, D-76131 Karlsruhe, Germany
[6] Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[7] Univ Bath, Dept Econ & Int Dev, Bath BA2 7AY, Avon, England
[8] Natl Food Agcy Denmark, Inst Toxicol, DK-3500 Vaerloese, Denmark
[9] DPR Nutr, Croydon Surrey CR0 5DG, England
[10] Nestle, CH-1000 Lausanne 26, Switzerland
[11] Procter & Gamble Eurocor, B-1853 Strombeek Bever, Belgium
[12] Univ Zurich, Vetsuisse Fac, CH-8057 Zurich, Switzerland
关键词
BRAFO; Benefit-risk analysis; Tiered approach; Natural foods; Macronutrient; Heat processing; QALYS;
D O I
10.1016/j.fct.2010.05.049
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
BRAFO stands for Benefit-Risk Analysis for Foods. This European Commission funded project aims at developing a framework that allows quantitative comparison of human health risks and benefits of foods and food compounds based on a common scale of measurement. A methodology group brought together methodologies from several disciplines relevant to the evaluation of risks and benefits in food. This group reviewed and assembled the methodologies available. They produced this guidance document that describes a tiered ('stepwise') approach for performing a risk and benefit assessment of foods. This process starts with pre-assessment and problem formulation to set the scope of the assessment. This includes defining two scenarios, the reference and an alternative that are compared in the assessment. The approach consists of four tiers. In many cases, a lower tier assessment in which risks and benefits are qualitatively evaluated may be sufficient to show a clear difference between the health impacts of the two scenarios. In other cases, increasingly sophisticated methods to integrate risks and benefits quantitatively are used at higher tiers to assess the net health impact. (C) 2010 ILSI Europe. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:S684 / S698
页数:15
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