A General and Highly Selective Cobalt-Catalyzed Hydrogenation of N-Heteroarenes under Mild Reaction Conditions

被引：135

作者：

Adam, Rosa ^{[1
]}

Cabrero-Antonino, Jose R. ^{[1
]}

Spannenberg, Anke ^{[1
]}

Junge, Kathrin ^{[1
]}

Jackstell, Ralf ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 12期

关键词：

cobalt; homogeneous catalysis; hydrogenation; nitrogen heterocycles; phosphines; DEFINED IRON-CATALYST; ASYMMETRIC ALKENE HYDROGENATION; MANGANESE PINCER COMPLEXES; X-RAY CHARACTERIZATION; CARBON-DIOXIDE; HOMOGENEOUS HYDROGENATION; HETEROAROMATIC-COMPOUNDS; GALIPEA-OFFICINALIS; QUINOLINE COMPOUNDS; BASE-METAL;

D O I：

10.1002/anie.201612290

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, a general and efficient method for the homogeneous cobalt-catalyzed hydrogenation of N-heterocycles, under mild reaction conditions, is reported. Key to success is the use of the tetradentate ligand tris(2-(diphenylphosphino)phenyl)phosphine). This non-noble metal catalyst system allows the selective hydrogenation of heteroarenes in the presence of a broad range of other sensitive reducible groups.

引用

页码：3216 / 3220

页数：5

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