Establishing the cut-off value of a screening method

被引：2

作者：

Steliopoulos, Panagiotis ^{[1
]}

机构：

[1] CVUA Karlsruhe, D-76187 Karlsruhe, Germany

来源：

ACCREDITATION AND QUALITY ASSURANCE | 2012年 / 17卷 / 05期

关键词：

Screening methods; Cut-off value; Prediction limits;

D O I：

10.1007/s00769-012-0923-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Generally, the cut-off point of a screening assay is defined through a one-sided prediction limit obtained from a given sample of blanks. Depending on the assumptions one is willing to make about the underlying data distribution, different types of prediction limits can be employed. In this paper, Monte Carlo simulations are used to illustrate the coverage performance of normal, lognormal and nonparametric prediction limits under normal and non-normal conditions.

引用

页码：543 / 547

页数：5

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