Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future

被引：57

作者：

Domino, Edward F. ^{[1
]}

Luby, Elliot D. ^{[2
,3
]}

机构：

[1] Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA

[2] Wayne State Univ, Dept Psychiat & Behav Sci, Detroit, MI USA

[3] Comprehens Psychiat Serv, Farmington Hills, MI USA

来源：

SCHIZOPHRENIA BULLETIN | 2012年 / 38卷 / 05期

关键词：

phencyclidine; drug model; drug of abuse; MESSENGER-RNA EXPRESSION; PREFRONTAL CORTEX; RECEPTOR-BINDING; DOPAMINE HYPOTHESIS; THOUGHT-DISORDER; NMDA ANTAGONIST; SCHIZOPHRENIA; PHENCYCLIDINE; KETAMINE; NEURONS;

D O I：

10.1093/schbul/sbs011

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.

引用

页码：914 / 919

页数：6

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