Strategies for the Prevention of Central Nervous System Complications in Patients with Langerhans Cell Histiocytosis The Problem of Neurodegenerative Syndrome

被引：10

作者：

Imashuku, Shinsaku ^{[1
]}

Arceci, Robert J. ^{[2
]}

机构：

[1] Takasago Seibu Hosp, Div Hematol, Takasago, Hyogo 6760812, Japan

[2] Univ Arizona, Coll Med, Childrens Ctr Canc & Blood Disorders, Dept Child Hlth,Phoenix Childrens Hosp, Phoenix, AZ 85004 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 05期

关键词：

Langerhans cell histiocytosis; Central nervous system; Diabetes insipidus; Neurodegenerative disease; Neuroinflammatory disease; NECROSIS-FACTOR-ALPHA; CENTRAL DIABETES-INSIPIDUS; DECOY RECEPTOR-3 DCR3; CEREBROSPINAL-FLUID; T-CELLS; MICROGLIAL ACTIVATION; DISEASE-ACTIVITY; ELEVATED LEVELS; SERUM-LEVELS; MATRIX METALLOPROTEINASES;

D O I：

10.1016/j.hoc.2015.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diseases of the central nervous system (CNS) are common in patients with Langerhans cell histiocytosis (LCH). Besides active LCH lesions, neurodegenerative (ND) lesions of the cerebellum and/or basal ganglia may occur as late sequelae of LCH. While the etiology of this ND disease remains unclear, biomarkers in cerebrospinal fluid (CSF) may reflect the activity of CNS disease in these patients. However, no well-planned CSF studies have yet been performed in patients at high risk for ND-CNS-LCH. Potential parallels with other neuroinflammatory/neurodegenerative diseases suggest the utility of examining these other disorders in establishing strategies for the prevention and/or treatment of ND-CNS-LCH.

引用

页码：875 / +

页数：20

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