Ex vivo expansion and engraftment potential of cord blood-derived CD34+ cells in NOD/SCID mice

被引：0

作者：

Fibbe, WE ^{[1
]}

Noort, WA ^{[1
]}

Schipper, F ^{[1
]}

Willemze, R ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Hematol, NL-2300 RC Leiden, Netherlands

来源：

HEMATOPOIETIC STEM CELLS 2000 BASIC AND CLINICAL SCIENCES | 2001年 / 938卷

关键词：

cord blood; CD34(+) stem/progenitor cells; NOD/SCID mice;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

For more than 10 years umbilical cord blood (UCB) has been used as an alternative source of hematopoietic stem cells for allogeneic transplantation. Although the clinical results are encouraging, UCB is associated with delayed engraftment. To address these issues we have used the NOD/SCID mouse model to study the engraftment potential of cord blood cells in more detail, to assess the engraftment potential of expanded megakaryocytic progenitor cells, and to study the effect of co-transplantation of mesenchymal stem cells on engraftment.

引用

页码：9 / 17

页数：9

共 50 条

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