Gene therapy of the ischemic lower limb - Therapeutic angiogenesis

被引：37
|
作者：
Bobek, Vladimir
Taltynov, Oliver
Pinterova, Daniela
Kolostova, Katarina
机构：
[1] Charles Univ Prague, Fac Med 3, Dept Tumor Biol, Prague 10034, Czech Republic
[2] Med Acad Wroclaw, Wroclaw, Poland
[3] Inst Expt Med, Dept Cell Ultrastruct & Mol Biol, Prague, Czech Republic
来源：
VASCULAR PHARMACOLOGY | 2006年 / 44卷 / 06期
关键词：
VEGF; therapeutic angiogenesis; plasmid; vector; PAOD;
D O I：
10.1016/j.vph.2006.03.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The limitations of surgical revascularisation and pharmacological treatment in peripheral arterial occlusive disease (PAOD) are well recognized. Therapeutic options for critical leg ischemia are consequently limited to percutaneous transluminal angioplasty (PTA) or surgical revascularisation. Unfortunately, many patients with critical leg ischemia are poor candidates for either procedure. Therapeutic angiogenesis is a novel promising tool to treat these patients. Experimental and clinical and trials of gene transfer for therapeutic angiogenesis have already shown some clinical efficacy. This review is focused on gene transfer techniques in preclinical and clinical therapeutic angiogenesis, angiogenic growth factors, vectors, delivery methods and routes. The results of clinical and experimental studies, safety and side effects of gene therapy, and the perspectives of future research are also discussed. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：395 / 405
页数：11
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