Cyclin D1 polymorphism in non-small cell lung cancer in a Portuguese population

被引：5
|
作者：
Catarino, R. [1 ]
Coelho, A. [1 ]
Nogueira, A. [1 ]
Araujo, A. [2 ]
Gomes, M. [1 ]
Lopes, C. [1 ,3 ]
Medeiros, R. [1 ,3 ,4 ]
机构：
[1] Inst Portugues Oncol Francisco Gentil, Mol Oncol GRP CI, P-4200072 Oporto, Portugal
[2] Inst Portugues Oncol Francisco Gentil, Dept Med Oncol, P-4200072 Oporto, Portugal
[3] Abel Salazar Inst Biomed Sci, ICBAS, Oporto, Portugal
[4] Portuguese League Canc NRNorte, Res Dept, LPCC, Oporto, Portugal
来源：
CANCER BIOMARKERS | 2012年 / 12卷 / 02期
关键词：
Cyclin D1; genetic polymorphism; NSCLC; GLUTATHIONE-S-TRANSFERASE; PROGNOSTIC-SIGNIFICANCE; SPLICE VARIANTS; RISK; EXPRESSION; CARCINOMA; GENOTYPE; OVEREXPRESSION; SUSCEPTIBILITY; AMPLIFICATION;
D O I：
10.3233/CBM-130294
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclin D1 (CCND1) is a key regulatory protein of the cell cycle. The purpose of our study was to assess the role of CCND1 genetic variants influencing the genetic susceptibility of non-small cell lung cancer (NSCLC). We conducted a study of 1234 individuals, including 892 controls and 342 cases. Individuals carrying two G-alleles have a 2-fold increased risk for the development of NSCLC and the waiting time for onset of NSCLC in these patients was 2 years earlier in comparison with other individuals. Our results may be important in contributing to the knowledge of the mechanisms involved in lung carcinogenesis.
引用
收藏
页码：65 / 72
页数：8
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