Celiac disease in the elderly

被引:19
|
作者
Johnson, Matthew W. [1 ]
Ellis, H. Julia
Asante, Max A.
Ciclitira, Paul J. [2 ]
机构
[1] Royal Surrey Hosp, London, England
[2] St Thomas Hosp, Dept Gastroenterol Res, London SE1 7EH, England
基金
美国国家卫生研究院;
关键词
celiac disease; elderly; investigation; medical management; older person;
D O I
10.1038/ncpgasthep1281
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Celiac disease is a common condition that is thought to affect 1 in 200 people throughout Europe and America, with prevalence rates reaching 1: 100 in Ireland. Improvements in the sensitivity and specificity of serological testing for celiac disease over the past 15 years have resulted in a larger number of diagnoses being made. Up to 34% of patients with newly diagnosed celiac disease are older than 60 years of age. The symptomatic presentation of celiac disease in elderly patients can be subtle, leading to a considerable delay in diagnosis and potential accumulation of associated secondary complications. Given that celiac disease is associated with significant morbidity and reduced life expectancy, physicians need to be aware of this condition and its occurrence in the current increasingly elderly population. Compliance with a strict gluten-free diet is as easily achieved in elderly patients as in younger patients, and has been reported to reduce the risks of cancer and lymphoma associated with celiac disease. This Review highlights age-related differences in the clinical presentation and investigation of patients with suspected celiac disease.
引用
收藏
页码:697 / 706
页数:10
相关论文
共 50 条
  • [1] Celiac disease in the elderly
    Matthew W Johnson
    H Julia Ellis
    Max A Asante
    Paul J Ciclitira
    [J]. Nature Clinical Practice Gastroenterology & Hepatology, 2008, 5 : 697 - 706
  • [2] Celiac Disease in the Elderly
    Charlotte K. Ching
    Benjamin Lebwohl
    [J]. Current Treatment Options in Gastroenterology, 2022, 20 (3) : 238 - 249
  • [3] Celiac Disease in the Elderly
    Rashtak, Shadi
    Murray, Joseph A.
    [J]. GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2009, 38 (03) : 433 - +
  • [4] Celiac disease in the elderly
    Patel, D
    Kalkat, P
    Baisch, D
    Zipser, R
    [J]. GERONTOLOGY, 2005, 51 (03) : 213 - 214
  • [5] CELIAC-DISEASE IN THE ELDERLY
    不详
    [J]. LANCET, 1984, 1 (8380): : 775 - 776
  • [6] Adult celiac disease in the elderly
    Hugh James Freeman
    [J]. World Journal of Gastroenterology, 2008, 14 (45) : 6911 - 6914
  • [7] Celiac disease diagnosed in the elderly
    Lurie, Yoav
    Landau, Dan-Avi
    Pfeffer, Jorge
    Oren, Ran
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 2008, 42 (01) : 59 - 61
  • [8] Celiac disease manifest in the elderly
    Majewska, Agata
    Niemczyk, Stanislaw
    Staszkow, Monika
    Matuszkiewicz-Rowinska, Joanna
    [J]. POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, 2009, 119 (04): : 269 - 271
  • [9] Adult celiac disease in the elderly
    Freeman, Hugh James
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (45) : 6911 - 6914
  • [10] CELIAC-DISEASE IN THE ELDERLY
    HANKEY, GL
    HOLMES, GKT
    [J]. GUT, 1994, 35 (01) : 65 - 67