Anaplastic multiple myeloma with MYC rearrangement

A 52-year-old man with rapidly progressive paraplegia was presented to us with paravertebral tumors. Lam-inectomy with tumor resection was performed, and pathological analysis of the tumor revealed compact pro-liferation of anaplastic plasmacytoid cells. G-band analysis of the tumor revealed a complex karyotype, including IgH/MYC translocation. The patient was diagnosed with anaplastic multiple myeloma (AMM) with MYC arrangement, and cytotoxic chemotherapy followed by autologous hematopoietic stem cell transplantation resulted in long-term disease-free remission. This is the first report describing a case of de novo AMM with MYC rearrangement, suggesting that conventional chemotherapy could be a treatment option for this formidable disease.